Figure 5

Histological changes of organs associated with infection. At 4 weeks post infection, tissues of mice infected with WT or ΔclpP strain were collected. The histology of animals infected with WT (A, B, and C) were compared to animals infected with ΔclpP (D, E, and F). Naive mice are depicted (G, H, and I) for comparison. Hematoxylin and eosin staining was used (× 20 magnification). Sections from liver and spleen were scored for severity of histiocytic inflammation from 1 to 4 at 4 weeks post-infection, and mean scores were compared using unpaired Student’s t-test (J and K). One asterisks, p < 0.05, two asterisks, p < 0.01, and three asterisks, p < 0.001.