Pathogenicity and escape to pre-existing immunity of a new genotype of swine influenza H1N2 virus that emerged in France in 2020

Table 1 Experimental design

Group ID	Vaccination with Respiporc^® Flu3 at 5 (D-28) and 8 (D-7) weeks of age	Inoculum
Group ID		1^st challenge at 9 weeks of age (D0)	2^nd challenge at 12 weeks of age (D21)
H1N1	No	272/20-H1_avN1	154/20-H1_avN2
H1N2	No	154/20-H1_avN2	154/20-H1_avN2
CONTROL	No	EMEM	none
H1N1 VACC	Yes	272/20-H1_avN1	154/20-H1_avN2
H1N2 VACC	Yes	154/20-H1_avN2	154/20-H1_avN2
CONTROL VACC	Yes	EMEM	none

272/20-H1_avN1 = A/Swine/France/29-200272-01/2020 (H1_avN1-HA clade 1C.2.1), 154/20-H1_avN2 = A/Swine/France/35-200154-01/2020 (H1_avN2-HA clade 1C.2.4), EMEM = Eagle’s Minimum Essential Medium (mock-inoculation).

ISSN: 1297-9716