Figure 9
ROC curves obtained by different methods and parameters to assess the antigen-specific cellular immune response of MAP-infected calves. Only values from 20 wpi onwards were considered. A IGRA data using the evaluation parameters cODPPDa und diffODPPDa – PPDb. B FCA data using the evaluation parameters “IFN-γ (MFI) in all CD4 + T cells, response to PPDj [x-fold vs. PPDp]” (designated “PPDj vs. PPDp”), “IFN-γ (MFI) in all CD4 + T cells, response to WCSj” (designated “WCSj”) and “IFN-γ (MFI) in all CD4 + T cells, response to WCSj [x-fold vs. WCSp]” (designated “WCSj vs. WCSp”). C IGRA data (cODPPDa) and FCA data using the evaluation parameters “IFN-γ (MFI) in all CD4 + T cells, response to WCSj” (designated “WCSj”) and “IFN-γ (MFI) in all CD4 + T cells, response to WCSj [x-fold vs. WCSp]” (designated “WCSj vs. WCSp”).