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Table 1 Timing of euthanasia and clinical signs

From: Transmission of Norwegian reindeer CWD to sheep by intracerebral inoculation results in an unusual phenotype and prion distribution

Animal

Time of euthanasia (mpi)

Reason for euthanasia

Clinical signs or disease prior to euthanasia

90530

17

Intercurrent disease

Lethargy, clinical hypocalcemia

90542

31

Intercurrent disease

Degenerative joint disease

90501

42

Study endpoint

Spontaneous smacking, reduced menace response

90506

42

Study endpoint

Abnormal mental status, spontaneous smacking, reduced menace response, positive scratch test, abnormal gait

90507

42

Study endpoint

Reduced menace response

90525

42

Study endpoint

Spontaneous smacking, teeth grinding, reduced menace response, positive scratch test, abnormal gait

  1. mpi months post-inoculation.