Figure 6
From: PRRSV hijacks DDX3X protein and induces ferroptosis to facilitate viral replication
Transcriptomics analysis of Marc-145 cells transfected with DDX3X-specific siRNA and infected with PRRSV. A PCA plot of RNA-seq data. B Heatmap of correlation between samples from different groups. C Transcript levels of PRRSV N, M, ORF1a, ORF1b, GP2, GP3, GP4 and GP5 genes. D Volcanic map of the DEGs. E Heatmap of the DEGs. F GO terms of the DEGs. The lower x-axis represents the number of genes annotated to GO terms, while the upper x-axis represents the proportion of the total number of genes. Red lines represent up-regulated genes, and blue lines represent down-regulated ones. G KEGG enrichment bubble plot. The abscissa was the rate of the number of DEGs to the total number of DEGs, with the ordinate being the KEGG pathway. Two-tailed Student’s t-test determined statistical analysis of comparisons, n = 3 ± SEM. The stars indicate significant differences (*P < 0.05 or **P < 0.001).