Figure 9
Functions and regulatory mechanisms of cadDX. In S. suis, cadDX is located within an 11K MGE that can autonomously form a circular structure. The presence of Cd2+ disrupts the repression of cadD by CadX, thereby contributing to cadmium resistance. CadX protects S. suis against oxidative stress by repressing cadD to prevent its excessive expression, which can be detrimental to the bacterium. Additionally, cadDX influences genes involved in the oxidative stress response, including fatty acid synthesis-related genes, PTS transport system-related genes, permeases, and FeoA, which contribute to oxidative stress resistance.