Figure 1

Illustration of the ASFV structure and genome. ASFV belongs to the family Asfarviridae and has an icosahedral enveloped virion. From the outside to the inside are the outer envelope, capsid, inner membrane, matrix shell, and genome. The genome of ASFV is dsDNA and encodes more than 150 ORFs of ∼50 structural proteins and 100 immunoregulatory proteins. Most structural proteins, such as pp62, pp220, p72, p30, and CD2v, are major components of ASF virus particles and play important roles in the process of virus attachment, entry, and replication. Other ASFV-encoded proteins, such as pC475, pDP71L, pA224, pO174L, and pNP1450L, are involved in mRNA modification, posttranslational modification, immune suppression, base excision repair, and transcription [131].