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Figure 7 | Veterinary Research

Figure 7

From: Porcine reproductive and respiratory syndrome virus degrades TANK-binding kinase 1 via chaperon-mediated autophagy to suppress type I interferon production and facilitate viral proliferation

Figure 7

Schematic model depicting that PRRSV inhibits IFN-I production by degrading TBK1 via CMA, thereby promoting viral proliferation. Mechanistically, PRRSV Nsp2 enhances the interaction between HSPA8 and TBK1, leading to LAMP2A-mediated translocation of TBK1 into lysosomes for degradation, which impedes downstream IRF3 signalling and IFN-I production.

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Veterinary Research

ISSN: 1297-9716