Figure 1

The helical wheel modeling of 12 alpha-helical cathelicidins. A ΔModoCATH1, B ΔModoCATH5, C ΔModoCATH6, D PMAP-36, E ΔPb-CATH4, F ΔHg-CATH, G BMAP-28, H EA-CATH1, I cc-CATH3, J HA-CATH, K ML-CATH and L PD-CATH. Helical wheel projection diagrams were created using HeliQuest with full window size and code size proportional to amino acid volume. Nonpolar residues are shown in yellow and grey, while polar (uncharged polar, negatively, and positively charged) residues are shown in purple, red, and blue, respectively. Cysteine and proline are indicated by green color. The size of the arrow (↓) represents the level of hydrophobic moment.