Table 2 Bactericidal activities of cathelicidins and bacteriocins against 8 standard strains
Antimicrobials | Minimal inhibitory concentration (μg/mL, μM) | |||||||
|---|---|---|---|---|---|---|---|---|
Escherichia coli | Pseudomonas aeruginosa | Staphylococcus aureus | Bacillus cereus | Enterococcus faecalis | Streptococcus agalactiae | Streptococcus dysgalactiae | Streptococcus equi subsp. zooepidemicus | |
ΔModoCath1 | 4 (1.1) | 10 (2.9) | 11 (3.2) | > 40 (10.5) | 10 (2.9) | > 40 (10.5) | > 40 (10.5) | 40 (10.5) |
ΔModoCath5 | 21 (5.8) | > 40 (11.0) | 6 (1.7) | 26 (7.3) | 10 (2.8) | > 40 (11.0) | > 40 (11.0) | > 40 (11.0) |
ΔModoCath6 | 25 (8.2) | > 40 (13.2) | > 40 (13.2) | > 40 (13.2) | > 40 (13.2) | > 40 (13.2) | > 40 (13.2) | > 40 (13.2) |
PMAP-36 | 3 (0.7) | 8 (1.9) | 9 (2.2) | 28 (6.7) | > 40 (9.6) | > 40 (9.6) | > 40 (9.6) | > 40 (9.6) |
PG-1 | 23 (10.0) | 20 (8.7) | 43 (18.8) | > 40 (17.5) | > 40 (17.5) | > 40 (17.5) | 32 (14.0) | > 40 (17.5) |
PR-35 | 15 (3.6) | > 40 (9.5) | > 40 (9.5) | > 40 (9.5) | > 40 (9.5) | > 40 (9.5) | > 40 (9.5) | > 40 (9.5) |
ΔPb-CATH4 | 5 (1.6) | 11 (3.5) | 4 (1.3) | > 40 (13.1) | > 40 (13.1) | > 40 (13.1) | > 40 (13.1) | 20 (6.6) |
ΔHg-CATH | 4 (1.3) | 5 (1.7) | > 40 (13.2) | > 40 (13.2) | > 40 (13.2) | > 40 (13.2) | 15 (4.9) | 15 (4.9) |
BMAP-28 | 4 (1.3) | 9 (2.9) | 5 (1.6) | 7 (2.2) | 15 (4.8) | > 40 (12.6) | > 40 (12.6) | > 40 (12.6) |
EA-CATH1 | 9 (2.9) | 19 (6.1) | 41 (13.4) | > 40 (13.1) | 30 (9.8) | > 40 (13.1) | > 40 (13.1) | > 40 (13.1) |
cc-CATH3 | 3 (0.9) | 4 (1.28) | 2 (0.6) | 4 (1.28) | 5 (1.5) | 4 (1.28) | 7 (2.0) | 5 (1.5) |
HA-CATH | 18 (3.9) | > 40 (8.6) | 26 (5.6) | 25 (5.4) | > 40 (8.6) | > 40 (8.6) | > 40 (8.6) | > 40 (8.6) |
ML-CATH | 2 (0.5) | 42 (10.6) | 2 (0.5) | 3 (0.8) | 5 (1.3) | 8 (2.0) | 14 (3.5) | 9 (2.3) |
PD-CATH | 7 (1.7) | 42 (10.3) | 3 (0.7) | 6 (1.5) | 6 (1.5) | 8 (2.0) | 18 (4.4) | 17 (4.2) |
Nisin | > 64 (19.2) | > 64 (19.2) | 2 (0.60) | 4 (1.2) | 16 (3.6) | 2 (0.60) | 4 (1.2) | 4 (1.2) |
Lysostaphin | > 160 (29.7) | > 160 (29.7) | 1 (0.2) | > 160 (29.7) | > 160 (29.7) | > 160 (29.7) | > 160 (29.7) | > 160 (29.7) |
Chloramphenicola | 3 (9.3) | 80 (247.6) | 8 (24.8) | 10 (31.0) | 10 (31.0) | 5 (15.5) | 4 (12.4) | 5 (15.5) |
Ampicillina | 5 (14.3) | > 640 (1831.7) | 2 (5.7) | 80 (228.8) | 10 (28.6) | 4 (11.4) | 2 (5.7) | 2 (5.7) |
Gentamicina | 1 (2.1) | 1 (2.1) | 1 (2.1) | 1 (2.1) | 90 (189.0) | 75 (157.5) | 15 (31.5) | 45 (94.5) |