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Table 3 Antimicrobial activity of cc-CATH3, PD-CATH, and ML-CATH against 8 field isolates from milk with high somatic cell counts

From: Bactericidal activities and biochemical features of 16 antimicrobial peptides against bovine-mastitis causative pathogens

 

Strains

Minimal inhibitory concentration (μg/mL, μM)

cc-CATH3

ML-CATH

PD-CATH

Chloramphenicola

Ampicillina

Gentamicina

Gram-negative bacteria

Aeromonas hydrophila

 > 160 (47.4)

160 (40.2)

160 (39.1)

5 (15.5)

 > 240 (686.4)

4 (8.4)

Gram-positive bacteria

Staphylococcus chromogenes

3 (0.9)

2 (0.5)

4 (1.0)

18 (55.8)

5 (14.3)

2 (4.2)

Staphylococcus haemolyticus

2 (0.6)

2 (0.5)

3 (0.7)

10 (31.0)

10 (28.6)

10 (20.9)

Staphylococcus xylosus

2 (0.6)

2 (0.5)

3 (0.7)

8 (24.8)

5 (14.3)

1 (2.1)

Staphylococcus epidermidis

2 (0.6)

2 (0.5)

3 (0.7)

5 (15.5)

5 (14.3)

4 (8.4)

Corynebacterium simulans

0.8 (0.2)

1 (0.3)

1 (0.2)

8 (24.8)

 > 240 (686.4)

10 (20.9)

Glutamicibacter halophytocola

2 (0.6)

2 (0.5)

1 (0.2)

3 (9.3)

15 (42.9)

3 (6.3)

Streptococcus uberis

4 (1.2)

3 (0.8)

5 (1.2)

50 (155.0)

 > 240 (686.4)

60 (125.6)

  1. aUsed as controls.
  2. CLSI breakpoints of ampicillin against Staphylococcus spp., Corynebacterium spp., and S. uberis are ≥ 0.25, 0.125 and 0.6 μg/mL, respectively.