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Figure 3 | Veterinary Research

Figure 3

From: African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation

Figure 3

Effect of depleting or supplying GSH on ASFV-mediated (MOI = 1) PAMs resistance to Ars-induced SGs formation at 12 hpi. (A) PAMs were mock- or ASFV-infected and treated with PBS, Ars, BSO, or Ars and BSO. The impact of BSO-mediated GSH depletion on SGs formation. Red arrows indicate SGs formation in ASFV-infected PAMs under BSO treatment. (B) The number of SG-positive, mock-infected, or ASFV-infected PAMs was recorded and quantified from at least five fields for each of the three biological repeats. (C) PAMs were mock-infected or ASFV-infected. PAMs were also treated with NAC (10 mM) with or without Ars (0.5 mM) and then fixed and processed for IFA.

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Veterinary Research

ISSN: 1297-9716