Figure 1
From: Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity
Figure created with BioRender.
Intrinsic versus innate immunity. During Intrinsic immunity, the constitutively expressed host restriction factors exert antiviral activities in different stages of viral life cycle. In contrast, invading viral DNA or RNA are recognized by specific host PRR (such as TLR7, RIG-I, and MDA5) during innate immunity that signal to induce IFN secretion, which further triggers the expression of numerous ISG to restrict viral replication.