Figure 2
From: Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity
Figure created with BioRender.
Intrinsic host restriction factors against SADS-CoV. The identified host restriction factors CH25H, TMEM53, and HDAC6 target different stages of SADS-CoV life cycle to inhibit viral replication: CH25H blocks S protein-mediated membrane fusion, TMEM53 disrupts the formation of viral RdRp complex, and HDAC6 might induce NSP8 degradation.