Figure 4
From: Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity
Figure created with BioRender.
Inhibition of type III IFN response by SADS-CoV. SADS-CoV NSP1 inhibits IFNλ production by inducing IRF1 degradation through the ubiquitin–proteasome pathway. SADS-CoV NS7a inhibits IFNλ production by cleaving IRF3 through activation of caspase-3 by interacting with AIFM1.