Figure 3

Increased gross pathological changes in cranial lung lobes of lambs after lower respiratory tract, but not upper respiratory tract inoculation with M. ovipneumoniae. A Representative lungs from lambs with upper and lower respiratory tract inoculation at eight weeks post inoculation with PBS or with M. ovipneumoniae. LCr—left cranial lung, RCr—right cranial lung, LCa—left caudal lung, RCa—right caudal lung, H heart. Arrows in the right panel point to consolidated lung tissue. B Gross pathological findings for lungs from individual animals at necropsy. One animal in the URT group developed a urinary tract disease and was euthanized prior to the experimental endpoint, so that no samples could be collected.