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Table 7 Histopathological scoring of lungs from sheep infected with PBS (control) or with M. ovipneumoniae- containing nasal-wash fluids through inoculation of the upper (URT) or lower respiratory tract (LRT)

From: Pathogen delivery route impacts disease severity in experimental Mycoplasma ovipneumoniae infection of domestic lambs

 

Control

(n = 5)

URT

(n = 4)

LRT

(n = 5)

P-value*

Pulmonary edema and congestion

 

 Cranial

3.4 ± 1.1

3.8 ± 0.5

3.2 ± 0.8

0.6631

 Caudal

3.2 ± 0.8

3.5 ± 0.6

3.6 ± 0.9

0.7212

Alveolar and interstitial inflammation

 

 Cranial

0.8 ± 1.1a

2.8 ± 0.5b

5.0 ± 1.2c

0.0002

 Caudal

0.2 ± 0.4

0.8 ± 1.0

1.0 ± 0.0

0.1207

Bronchiolar inflammation

 

 Cranial

0.2 ± 0.4a

1.5 ± 0.6a

4.4 ± 1.5b

0.0001

 Caudal

0.0 ± 0.0

0.0 ± 0.0

0.2 ± 0.4

0.4406

BALT hyperplasia

 

 Cranial

0.6 ± 0.5a

3.3 ± 1.0b

4.2 ± 0.8b

 < 0.0001

 Caudal

0.4 ± 0.5

1.0 ± 0.0

1.2 ± 0.8

0.1406

Total score

8.8 ± 3.1a

11.3 ± 1.3a

22.8 ± 4.1b

 < 0.0001

  1. *ANOVA analysis. P values considered statistically significant are bolded.
  2. a,b,cDifferent letters denote statistically significant differences (P < 0.05) in Tukey’s pairwise comparisons test.