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Figure 6 | Veterinary Research

Figure 6

From: Deltacoronavirus HKU11, HKU13, PDCoV (HKU15) and HKU17 spike pseudoviruses enter avian DF-1 cells via clathrin-mediated endocytosis in a Rab5-, Rab7- and pH-dependent manner

Figure 6

Schematic illustrating HKU11, HKU13 and HKU17 pseudovirus entry into DF1 cells. DCoV attaches to the cell surface and is internalized via clathrin-mediated endocytosis with the help of dynamin-2. The internalized virus is taken up into early endosomes in a Rab5a-dependent process. Through endosome maturation, virus-containing endosomes acquire Rab7 and become luminal components of Rab7-containing late endosomes. A low pH and cathepsin L/B are required for avian DCoV internalization and the subsequent transport steps to release viral genomic RNA (gRNA) into the cytoplasm.

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Veterinary Research

ISSN: 1297-9716